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So longas the clinician correctly assesses the primarypathophysiologic derangement and selectsthe appropriate strategy to address thisderangement, the patient likely stands to ben-e?t.
In anearly example, the brains of 10 cognitively normal elderlywomen were found to have Alzheimer’s plaques at autopsy(Katzman et al., 1988). In a similar fashion to the Nutlins, spiro-oxindoles bind MDM2 by mimicking the interactions of crucial hydrophobic resi-dues (Phe19, Trp23 and Leu26) in the p53 peptide [93, 94]. noradrenaline (NA)release is inhibited by NA (?2 receptor), dopa-mine, adenosine, prostaglandins and enkephalinswhile isoprenaline (?2 receptor) and angiotensin(AT1 receptor) increase NA release.